Honestly, I think there is a lot of similarities between unikernels, at least the one I'm active with and qubes. The big difference to me is that qubes is more desktop/consumer focused and nanos (the one I'm involved with) is more server-focused but the same sort of ideology/principles gets exposed - just at varying levels and because of the end environment they get architected differently.
Unless you rely on security through compartmentalization. See: https://qubes-os.org